Characteristics of scratching behavior induced by some chemical mediators in hairless mice.

Abstract

To find the characteristics of scratching behavior in hairless mice (HR-1), compound 48/80 and some putative chemical mediators of allergic reaction were injected intradermally into the backs of mice, and the number of scratching behaviors was measured. As reference mice, NC/Nga, ICR, and ddY mice were used. Scratching behavior in HR-1 and ICR mice was increased dose-dependently by compound 48/80. The same result was also observed with NC/Nga and ddY mice. However, the response in NC/Nga and ddY mice was far less than those of HR-1 and ICR mice. Similar to NC/Nga and ddY mice, HR-1 mice showed less sensitivity to histamine than ICR mice. On the other hand, the HR-1 mice showed a high response to serotonin compared with those of the NC/Nga and ddY mice. The scratching behavior in HR-1 mice induced by substance P was increased, but the effect was less potent than those in NC/Nga, ICR, and ddY mice. These results suggest that the scratching behavior induced by compound 48/80 in HR-1 mice is mainly attributable to serotonin.

• Authors: Miho Takubo, Yuhki Ueda, Rie Yatsuzuka, Shuishi Jiang, Yoko Fujii, Chiaki Kamei
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 100 Issue 4 Pg. 285-8 (Apr 2006) ISSN: 1347-8613 [Print] Japan
• PMID: 16565575 (Publication Type: Journal Article)

Chemical References

• Antipruritics
• Serotonin Antagonists
• Serotonin
• p-Methoxy-N-methylphenethylamine
• Histamine
• Methysergide

Topics

• Animals
• Antipruritics (pharmacology)
• Behavior, Animal (drug effects)
• Dermatitis, Atopic (chemically induced, prevention & control)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Histamine (toxicity)
• Methysergide (pharmacology)
• Mice
• Mice, Hairless
• Mice, Inbred ICR
• Pruritus (chemically induced, prevention & control)
• Serotonin (toxicity)
• Serotonin Antagonists (pharmacology)
• Species Specificity
• p-Methoxy-N-methylphenethylamine (antagonists & inhibitors, toxicity)