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p-Methoxy-N-methylphenethylamine

A potent mast cell degranulator. It is involved in histamine release.
Also Known As:
Agent 48-80; BW 48-80; Compound 48-80; Preparation 48-80; Agent 48 80; Agent 4880; BW 48 80; BW 4880; Compound 48 80; Compound 4880; Preparation 48 80; Preparation 4880; p Methoxy N methylphenethylamine; Phenethylamine, p-methoxy-N-methyl-
Networked: 634 relevant articles (21 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shin, Tae-Yong: 22 articles (01/2017 - 08/2002)
2. Kim, Sang-Hyun: 21 articles (04/2022 - 08/2002)
3. Kim, Hyung-Min: 17 articles (01/2017 - 01/2002)
4. Hong, Seung-Heon: 13 articles (04/2019 - 01/2002)
5. Kim, H M: 12 articles (05/2012 - 01/2000)
6. Song, Chang Ho: 11 articles (02/2018 - 10/2005)
7. Chai, Ok Hee: 11 articles (07/2017 - 10/2005)
8. Jeong, Hyun-Ja: 10 articles (01/2017 - 10/2003)
9. Shin, T Y: 9 articles (11/2013 - 01/2000)
10. Kim, Su-Jin: 8 articles (04/2017 - 04/2005)

Related Diseases

1. Edema (Dropsy)
2. Anaphylaxis (Anaphylactic Shock)
3. Hyperalgesia
4. Allergic Rhinitis
07/01/2003 - "Furthermore, NBGS significantly reduced in vitro histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 30 and 100 microg/ml. These results suggest that NBGS may be clinically effective in alleviating the nasal symptoms of allergic rhinitis, probably by inhibiting both histamine release from mast cells and nasal vascular permeability."
10/11/2002 - "The action of compound 48/80 to release mast cell-derived histamine in the nose mimics many of the nasal responses associated with allergic rhinitis, extravascular leakage and decreased nasal patency. "
11/01/2000 - "Frequencies of pathological skin reactivity to single vasomotor agents and saline in the control group of healthy subjects and in the allergic rhinitis patients group are shown in Table 1. In the control group, frequencies of normal skin reactivity to papaverine [p(= 1.8 x 10(-7)) < 0.01], metacholine [p(= 4.3 x 10(-6)) < 0.01], histamine [p(= 4.3 x 10(-6)) < 0.01], compound 48/80 [p(= 1.8 x 10(-7) < 0.01] and saline [p(= 6.9 x 10(-4)) < 0.01] were significantly greater than frequencies of pathological skin reactivity. "
01/01/2000 - "Seventy four perennial non-allergic rhinitis patients and fourty two healthy subjects were undergone to intradermal testing with papaverine (5 mg/ml), metacholine (0.02, 0.2 and 2.0 mg/ml), histamine (0.01, 0.1 and 10.0 micrograms/ml) and compound 48/80 (0.01, 0.1, 1.0 and 10.0 micrograms/ml). "
01/01/2009 - "Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release."
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Histamine (Histamine Dihydrochloride)
2. Bradykinin
3. Diphenhydramine (Benadryl)
4. Substance P
5. Methysergide (Sansert)
6. Immunoglobulin E (IgE)
7. Antigens
8. Cytokines
9. Serotonin (5 Hydroxytryptamine)
10. Dinoprostone (PGE2)

Related Therapies and Procedures

1. Intradermal Injections
2. Intravenous Injections
3. Injections
4. Controlled Hypotension
5. Intraperitoneal Injections