Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is an important public health problem. Although serotonin is believed to be an important neurotransmitter in the etiology of this disorder, it remains unclear which specific 5-HT receptors are involved in regulating the symptoms of ADHD. Previous studies have provided favorable evidence for the association of ADHD with both the serotonin transporter gene and serotonin 1B receptor gene. To further investigate the role of other genes of the serotonergic pathway in ADHD, the current study examined variants of the serotonin 4 receptor gene in a relatively large sample of ADHD nuclear families. The T allele of the 83097 C>T polymorphism of HTR4 showed a tendency of preferential transmission to probands with ADHD (chi(2)=2.699, P=0.100). When haplotype TDT analysis of HTR4 was performed, we further found that the C/G haplotype of the 83097 C>T and 83198 A>G polymorphisms (chi(2)=8.783, P=0.003) and the C/G/C haplotype of these and the -36 C>T polymorphism (chi(2)=5.762, P=0.016) were under-transmitted to probands with ADHD. These results suggest that the HTR4 gene may play a role in the genetic predisposition to ADHD.

• Authors: Jun Li, Yufeng Wang, Rulun Zhou, Bing Wang, Haobo Zhang, Li Yang, Stephen V Faraone
• Journal: Neuroscience letters (Neurosci Lett) Vol. 401 Issue 1-2 Pg. 6-9 (Jun 19 2006) ISSN: 0304-3940 [Print] Ireland
• PMID: 16563621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Serotonin, 5-HT4
• Serotonin

Topics

• Asian People (ethnology, genetics)
• Attention Deficit Disorder with Hyperactivity (ethnology, genetics, physiopathology)
• Brain (metabolism, physiopathology)
• Brain Chemistry (genetics)
• Child
• DNA Mutational Analysis
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genetic Testing
• Genotype
• Haplotypes (genetics)
• Humans
• Inheritance Patterns (genetics)
• Linkage Disequilibrium (genetics)
• Male
• Polymorphism, Genetic (genetics)
• Receptors, Serotonin, 5-HT4 (genetics)
• Serotonin (metabolism)