Oxidized low-density lipoprotein and beta2-glycoprotein I in patients with systemic lupus erythematosus and increased carotid intima-media thickness: implications in autoimmune-mediated atherosclerosis.

Abstract

Oxidative stress and LDL modification (oxLDL) are early pro-atherogenic events. OxLDL binds beta2GPI producing immunogenic oxLDL/beta2GPI complexes. Antibodies to these complexes have been associated with arterial thrombosis in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Circulating oxLDL/beta2GPI complexes, IgG and IgM antibodies to these complexes were measured by ELISA in 30 SLE patients asymptomatic for cardiovascular disease (mean age 31 years) and 27 age/sex matched healthy controls. Carotid intima-media thickness (IMT) was measured by ultrasound in all patients and controls. Forty-seven percent of SLE presented plaques (median IMT of 0.65 +/- 0.12 mm) while only 7% of the controls had plaques (median IMT of 0.50 +/- 0.04 mm, P < 0.001). Median optical density (OD450nm) for oxLDL/beta2GPI complexes in SLE was 0.244 +/- 0.07, higher than controls (0.174 +/- 0.09, P < 0.001). Median OD for IgG anti-oxLDL/beta2GPI antibodies was also higher in SLE (0.297 +/- 0.26) compared to controls (0.194 +/- 0.07, P < 0.001) while the median OD for IgM antibodies in SLE (0.444 +/- 0.46) was not different than controls (0.326 +/- 0.22, P = 0.267). There was no correlation between IMT and oxLDL/beta2GPI complexes, IgG or IgM antibodies, possibly reflecting the complex interrelationship between these serologic elements and tissue factors in the arterial wall. These results support the hypothesis that oxLDL/beta2GPI complexes and IgG (not IgM) anti-oxLDL/beta2GPI antibodies contribute to the development of autoimmune-mediated atherosclerosis.

• Authors: L R Lopez, M Salazar-Paramo, C Palafox-Sanchez, B L Hurley, E Matsuura, I Garcia-De La Torre
• Journal: Lupus (Lupus) Vol. 15 Issue 2 Pg. 80-6 ( 2006) ISSN: 0961-2033 [Print] England
• PMID: 16539278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins
• Autoantibodies
• Biomarkers
• Glycoproteins
• Immunoglobulin G
• Immunoglobulin M
• Lipoproteins, LDL
• beta 2-Glycoprotein I
• oxidized low density lipoprotein

Topics

• Adolescent
• Adult
• Apolipoproteins (blood)
• Atherosclerosis (etiology)
• Autoantibodies (blood)
• Biomarkers (blood)
• Carotid Arteries (pathology)
• Female
• Glycoproteins (blood, immunology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Lipoproteins, LDL (blood, immunology)
• Lupus Erythematosus, Systemic (blood, complications)
• Male
• Middle Aged
• Oxidation-Reduction
• Oxidative Stress
• Risk Factors
• Tunica Intima (pathology)
• Tunica Media (pathology)
• beta 2-Glycoprotein I