[Better treatment for patients with colorectal liver metastases].
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| Abstract |
Three patients, 61, 58 and 63 years old, presented with non-resectable liver metastases from colorectal cancer. The first patient, a man, who had a solitary lesion in the liver and severe cardiovascular morbidity, was successfully treated with laser-induced interstitial thermotherapy. The second patient, a woman, had large multiple liver metastases and two concomitant isolated pulmonary metastases. Following chemotherapy with fluorouracil, leucovorin and oxaliplatin, all lesions were downsized and a hemihepatectomy and pulmonary wedge resections were able to be performed in two stages. At the last follow-up, both patients were disease-free after 12 and 24 months respectively. The third patient, a man, presenting with multiple synchronous liver metastases, showed a significant decrease of hepatic tumour involvement after six courses of capecitabine. At present he is in a good condition and his disease is stable. Surgical resection ofcolorectal liver metastases leads to a 5-year survival rate of up to 45% in selected patients. Unfortunately, only 10 to 20% of patients are amenable to surgical resection. In the remaining group, a combination of new treatment options using local tumour ablative therapies and novel chemotherapeutic regimens provide alternative strategies with the potential of long-term survival.
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| Authors | D A Wicherts, R J de Haas, I H M Borel Rinkes, E E Voest, R van Hillegersberg |
| Journal | Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 150 Issue 7 Pg. 345-51 (Feb 18 2006) ISSN: 0028-2162 [Print] Netherlands |
| Vernacular Title | Betere behandelingsmogelijkheden voor patiënten met colorectale levermetastasen. |
| PMID | 16523794 (Publication Type: Case Reports, English Abstract, Journal Article) |
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