Cystic panfolliculoma.

Abstract

Panfolliculoma is a rare follicular neoplasm with differentiation toward both upper (infundibulum and isthmus) and lower (stem, hair matrix, and bulb) segments of a hair follicle. We present an unusual case of cystic panfolliculoma. A 33-year-old Hispanic woman presented with an 8-month history of a 3.0-cm cystic scalp mass. The lesion was excised, and the histologic sections showed a cystic follicular neoplasm that contained corneocytes in basket-woven and laminated array, trichohyalin granules of the inner root sheath, germinative cells, papillae, matrical cells, and "shadow" cells. Cytokeratin 903 and cytokeratin 5/6 immunostains uniformly highlight the tumor cells. Ber-EP4 strongly labels the germinative cells but not the follicular papillae. CD34 labels the surrounding fibrotic stroma and focally the epithelial component.

• Authors: Mai P Hoang, Brian M Levenson
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 130 Issue 3 Pg. 389-92 (Mar 2006) ISSN: 1543-2165 [Electronic] United States
• PMID: 16519571 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• human epithelial antigen-125
• Keratins

Topics

• Adult
• Biomarkers, Tumor (analysis)
• Epidermal Cyst (chemistry, pathology, surgery)
• Female
• Follicular Cyst (chemistry, pathology, surgery)
• Hair Follicle (pathology)
• Humans
• Keratins (analysis)
• Neoplasms, Basal Cell (chemistry, pathology, surgery)
• Skin (chemistry, pathology)
• Skin Neoplasms (chemistry, pathology, surgery)