Abstract | BACKGROUND: Oxidative stress has emerged as an invariable feature of calculogenesis, the process of stone formation. The cytoprotective action of low molecular weight heparin ( LMWH) in calcium oxalate-induced oxidative renal injury in experimental calculogenesis was studied. METHODS: RESULTS: The extent of oxidative damage was indicated by the increased lipid peroxidation in the renal tissues of gentamicin- and ammonium oxalate-administered groups. The decline in the antioxidative status of the stone forming kidneys further confirmed the oxidative stress to renal cells. The extensive nephritic damage in the form of proteinuria was quite evident and the injured status of the tissue was reflected in the significant alterations of the few membrane associated enzyme levels in urine and the kidney. LMWH restricted all the cyto-oxidative ill effects of ammonium oxalate and gentamicin. CONCLUSION:
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Authors | Arjunan Rajeswari, Palaninathan Varalakshmi |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 370
Issue 1-2
Pg. 108-14
(Aug 2006)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 16516183
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Biomarkers
- Heparin, Low-Molecular-Weight
- Oxalates
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Topics |
- Animals
- Antioxidants
(metabolism)
- Biomarkers
- Body Weight
(drug effects)
- Heparin, Low-Molecular-Weight
(pharmacology)
- Kidney
(drug effects, injuries, metabolism, pathology)
- Male
- Organ Size
(drug effects)
- Oxalates
(pharmacology)
- Oxidation-Reduction
- Oxidative Stress
- Rats
- Rats, Wistar
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