High dose anticholinergic therapy (biperiden) in dystonia.

Abstract

We studied the effect of biperiden in the treatment of dystonia in six patients aged 15-30 years. Five patients had generalized and one patient had segmental dystonia. Biperiden was started at a dose of 2 mg/day and was gradually increased to 40 mg/day in a few weeks. All patients had clinically significant response in varying degrees after a mean follow up of 1.9 years. Three patients showed considerable or dramatic benefit. The 40 mg/day was generally well tolerated. High dose anticholinergic therapy is effective in the management of torsion dystonia.

• Authors: N S Oztekin, S S Saygi, T Dalkara, I Senses, T Zileli
• Journal: Clinical neurology and neurosurgery (Clin Neurol Neurosurg) Vol. 93 Issue 1 Pg. 35-7 ( 1991) ISSN: 0303-8467 [Print] Netherlands
• PMID: 1651189 (Publication Type: Journal Article)

Chemical References

• Biperiden

Topics

• Adolescent
• Adult
• Biperiden (administration & dosage)
• Dose-Response Relationship, Drug
• Dystonia (drug therapy)
• Female
• Humans
• Male