Abstract | OBJECTIVE: DESIGN: Single-center, prospective, randomized, controlled, unblinded study. SETTING: General intensive care department of a tertiary-care, university-affiliated hospital. PATIENTS: A total of 100 patients with acute lung injury, diagnosed according to the American-European Consensus Conference on ARDS. INTERVENTIONS: Patients were randomized to receive the standard isonitrogenous, isocaloric enteral diet or the standard diet supplemented with EPA and GLA for 14 days. MEASUREMENTS AND MAIN RESULTS: Patient demographics, Acute Physiology and Chronic Health Evaluation II score, and type of admission were noted at admission. Compared with baseline oxygenation (EPA + GLA group vs. control group), by days 4 and 7, patients receiving the EPA + GLA diet showed significant improvement in oxygenation (PaO(2)/FIO(2), 317.3 +/- 99.5 vs. 214.3 +/- 56.4 and 296.5 +/- 165.3 vs. 236.3 +/- 79.8, respectively; p < .05). Compliance was significantly higher in the EPA + GLA group observed at day 7 (55.1 +/- 46.5 vs. 35.2 +/- 20.0 mL/mbar, p < .05). No significant difference was found in nutritional variables. Resting energy expenditure was significantly higher in patients in the EPA + GLA group, but their body mass index was also higher (p < .05). A significant difference was found in length of ventilation (p < .04) in favor of the EPA + GLA group. There was no between-group difference in survival. CONCLUSIONS:
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Authors | Pierre Singer, Myriam Theilla, Haran Fisher, Lilly Gibstein, Elad Grozovski, Jonathan Cohen |
Journal | Critical care medicine
(Crit Care Med)
Vol. 34
Issue 4
Pg. 1033-8
(Apr 2006)
ISSN: 0090-3493 [Print] United States |
PMID | 16484911
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Comment)
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Chemical References |
- gamma-Linolenic Acid
- Eicosapentaenoic Acid
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Topics |
- Adult
- Eicosapentaenoic Acid
(therapeutic use)
- Enteral Nutrition
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Respiration, Artificial
- Respiratory Distress Syndrome
(therapy)
- Treatment Outcome
- gamma-Linolenic Acid
(therapeutic use)
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