Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation.

Abstract

OBJECTIVES:

To compare the efficacy of sildenafil (Viagra) only, sildenafil plus topical anesthetic cream (EMLA), and topical EMLA-cream-only to that of placebo in treating premature ejaculation.

METHODS:

A total of 84 patients were enrolled in this study. The duration of premature ejaculation in the patients ranged from 9 to 60 months (mean 32.5 +/- 14.6). Patients were randomized into four groups. Group 1 consisted of 20 patients who took placebo for 2 months. Groups 2 and 3 consisted of 20 and 22 patients, respectively, and they received 50 mg sildenafil 45 minutes before coitus for 2 months. In addition, patients in group 3 applied topical EMLA cream to the glans penis 15 minutes before coitus. The 22 patients in group 4 used topical EMLA-cream-only. After at least eight sexual attempts, the patients' clinical responses were assessed using the patient self-description method. Effectiveness was described as improvement plus cure.

RESULTS:

The effectiveness was 40% in group 1, 55% in group 2, 86.4% in group 3, and 77.3% in group 4. Of the groups, a significant difference was found in the effectiveness of the treatments (Pearson chi-square= 0.00). No significant difference was found between groups 1 and 2 (P = 0.26). Efficacy was more successful in groups 3 and 4 than in the others (P = 0.00). The difference between groups 3 and 4 was not significant (Pearson chi-square = 0.42).

CONCLUSIONS:

Sildenafil-only was not superior to placebo or combination treatment. Topical EMLA-cream-only had equal effectiveness to that of sildenafil plus topical EMLA treatment. The use of topical EMLA-cream-only seems to be an effective treatment of premature ejaculation.

• Authors: Ali Atan, M Murad Basar, Altug Tuncel, Mehmet Ferhat, Koray Agras, Umit Tekdogan
• Journal: Urology (Urology) Vol. 67 Issue 2 Pg. 388-91 (Feb 2006) ISSN: 1527-9995 [Electronic] United States
• PMID: 16461091 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Local
• Lidocaine, Prilocaine Drug Combination
• Ointments
• Phosphodiesterase Inhibitors
• Piperazines
• Purines
• Sulfones
• Prilocaine
• Lidocaine
• Sildenafil Citrate

Topics

• Administration, Topical
• Adult
• Anesthetics, Local (administration & dosage)
• Drug Therapy, Combination
• Ejaculation (drug effects)
• Humans
• Lidocaine (administration & dosage)
• Lidocaine, Prilocaine Drug Combination
• Male
• Middle Aged
• Ointments
• Phosphodiesterase Inhibitors (administration & dosage)
• Piperazines (administration & dosage)
• Prilocaine (administration & dosage)
• Purines
• Sexual Dysfunction, Physiological (drug therapy)
• Sildenafil Citrate
• Sulfones
• Time Factors