Abstract | BACKGROUND: OBJECTIVE: We compared the metabolic effects of repeated ingestion of glutamine and glutamate in COPD patients and in age-matched healthy control subjects. DESIGN: On 3 d separated by intervals of > or = 2 d, a protocol of primed constant and continuous infusion of [2H5] phenylalanine and [2H2] tyrosine was performed for 3 h in 8 stable male COPD patients and 8 healthy control subjects. After a 90-min tracer infusion, all subjects ingested a glutamine or glutamate drink or the same amount of water every 20 min for 80 min. Blood samples were taken at the end of the postabsorptive and ingestion periods to test for effects on plasma amino acid and substrate concentrations and whole-body protein turnover. RESULTS:
Glutamate but not glutamine ingestion resulted in higher plasma ornithine concentrations than did water ingestion (P < 0.01). The change in plasma arginine, citrulline, and urea concentrations was significantly (P < 0.01) higher after glutamine ingestion than after water or glutamate ingestion. Whole-body protein turnover decreased overall, independent of the drink consumed. CONCLUSIONS:
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Authors | Erica P A Rutten, Marielle P K J Engelen, Emiel F M Wouters, Annemie M W J Schols, Nicolaas E P Deutz |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 83
Issue 1
Pg. 115-23
(Jan 2006)
ISSN: 0002-9165 [Print] United States |
PMID | 16400059
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Glutamine
- Glutamic Acid
- Deuterium
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Topics |
- Aged
- Amino Acids
(blood, metabolism)
- Case-Control Studies
- Deuterium
- Dietary Supplements
- Glutamic Acid
(administration & dosage, blood, metabolism)
- Glutamine
(administration & dosage, blood, metabolism)
- Health Status
- Humans
- Male
- Middle Aged
- Muscle, Skeletal
(metabolism)
- Postprandial Period
- Pulmonary Disease, Chronic Obstructive
(blood, metabolism)
- Respiratory Function Tests
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