Abstract | OBJECTIVE: PATIENTS AND MEASUREMENTS: Two sisters, aged 46 and 58, respectively, at the time of diagnosis, were found to have Cushing's syndrome due to AIMAH. We performed provocation tests with various materials and reverse transcription polymerase chain reaction (RT-PCR) with their resected adrenal tissues to examine the hyper-responsiveness to steroidogenesis and the overexpression of related receptors, respectively. RESULTS: CONCLUSION: The expression of ectopic vasopressin V1b and V2 receptors may be involved in the aetiology of AIMAH, at least in the case of the sibling patients presented here.
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Authors | Sihoon Lee, Ranjoo Hwang, Junho Lee, Yumie Rhee, Dae Jung Kim, Ung-Il Chung, Sung-Kil Lim |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 63
Issue 6
Pg. 625-30
(Dec 2005)
ISSN: 0300-0664 [Print] England |
PMID | 16343095
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Receptors, Vasopressin
- Arginine Vasopressin
- Hydrocortisone
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Topics |
- Adrenal Glands
(diagnostic imaging, metabolism)
- Adrenal Hyperplasia, Congenital
(diagnostic imaging, genetics, metabolism)
- Arginine Vasopressin
- Female
- Gene Expression
- Humans
- Hydrocortisone
(blood, metabolism)
- Middle Aged
- Pedigree
- RNA, Messenger
(analysis)
- Receptors, Vasopressin
(genetics, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Tomography, X-Ray Computed
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