Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy.

Abstract

BACKGROUND:

Lonafarnib (SCH66336) is a nonpeptidomimetic farnesyl transferase inhibitor that has demonstrated significant preclinical activity against chronic myelogenous leukemia (CML) cells and in CML animal models.

METHODS:

In the current study, the efficacy of lonafarnib was investigated in patients with CML in the chronic or accelerated phase that was resistant or intolerant to imatinib. Thirteen patients with CML in the chronic (n = 6 patients) or accelerated (n = 7 patients) phase were treated with lonafarnib at a dose of 200 mg orally twice daily. Ten patients had failed therapy with imatinib and 3 patients were intolerant to imatinib. The median age of the patients was 62 years (range, 38-80 yrs) and the median time from the diagnosis of CML to therapy with lonafarnib was 5 years (range, 0.3-13 yrs). In addition to imatinib mesylate, all patients had received prior therapy with interferon-alpha and seven patients had received other treatments. The median duration of therapy with lonafarnib was 8 weeks (range, 2-41 wks).

RESULTS:

Two patients responded. One patient in the accelerated phase of CML returned to the chronic phase, a response that lasted for 3 months. Another patient with chronic phase disease had lowering of the leukocyte count without the need for hydroxyurea and normalization of the differential count that lasted for 5 months. The most common adverse event was diarrhea, which was noted in 11 patients (84%) (Grade > or = 3 in 4 patients; 31%; toxicity was graded according to the National Cancer Institute Common Toxicity Criteria [version 2.0]). Therapy was discontinued in one patient because of diarrhea not responding to dose adjustments.

CONCLUSIONS:

Single-agent lonafarnib appears to have clinical activity in a small proportion of patients with CML refractory to imatinib.

• Authors: Gautam Borthakur, Hagop Kantarjian, George Daley, Moshe Talpaz, Susan O'Brien, Guillermo Garcia-Manero, Francis Giles, Stefan Faderl, Mary Sugrue, Jorge Cortes
• Journal: Cancer (Cancer) Vol. 106 Issue 2 Pg. 346-52 (Jan 15 2006) ISSN: 0008-543X [Print] United States
• PMID: 16342165 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Piperidines
• Pyridines
• Pyrimidines
• Imatinib Mesylate
• Farnesyltranstransferase
• lonafarnib

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (therapeutic use)
• Benzamides
• Drug Resistance, Neoplasm
• Farnesyltranstransferase (antagonists & inhibitors)
• Female
• Humans
• Imatinib Mesylate
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy)
• Male
• Middle Aged
• Pilot Projects
• Piperazines (therapeutic use)
• Piperidines (adverse effects, therapeutic use)
• Pyridines (adverse effects, therapeutic use)
• Pyrimidines (therapeutic use)