[The application of gonadotropin in treatment of male central hypogonadism].

Abstract

OBJECTIVE:

To observe the efficacy of human chorionic gonadotrophin (hCG) and hCG plus human menopausal gonadotropin (HMG) for central hypogonadism in male patients.

METHODS:

64 men with central hypogonadism were recruited in this study, including 19 patients with Kallmann syndrome, 41 patients with idiopathic hypogonadotrophic hypogonadism (IHH) and 4 patients with hypogonadism after brain surgery. 33 patients were treated with hCG 1500 IU intramuscularly twice a week, whereas 31 patients were treated with intramuscular hCG 1500 IU plus HMG 75 IU twice a week, for at least 6 months.

RESULTS:

After treatment, all patients felt stronger physically and 42/64 patients developed beard, pubes or armpit hair. The testis volume enlarged significantly [(3.08 +/- 2.44) ml vs (8.92 +/- 5.37) ml, P < 0.001], and serum follicle-stimulating hormone, luteinizing hormone and testosterone concentrations were higher significantly than those before treatment (P < 0.05). 6/64 patients underwent spermatorrhea and 2 patient were found to have spermatogenesis. If judged by the testis volume, 52 patients (81.2%) were effective and 12 patients were ineffective.

CONCLUSIONS:

For male patients with the central hypogonadism, hCG and hCG plus HMG can promote the pubertal development and maturation of second sex characteristics, as well as enhance the physical strength; in some patients both androgen production and spermatogenesis can be achieved.

• Authors: Fu-song Di, Yu-gui Cui, Yue Jia
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 44 Issue 11 Pg. 836-9 (Nov 2005) ISSN: 0578-1426 [Print] China
• PMID: 16316564 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chorionic Gonadotropin
• Menotropins

Topics

• Adolescent
• Adult
• Chorionic Gonadotropin (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Humans
• Hypogonadism (drug therapy)
• Injections, Intramuscular
• Male
• Menotropins (administration & dosage, therapeutic use)