[An interesting change of E-selectin in cimetidine administration during anticancer drug use].

Abstract

E-selectin is an adhesion molecule developed as an important material for hematogenous metastasis of cancer cells on vascular endothelial cells. It is expected that if we can restrain a manifestation of E-selectin then hematogenous metastasis can be restrained. We divided gastric cancer and the colorectal cancer patients, who performed chemotherapy, into two groups of cimetidine administrated group and a non-administration group, and reviewed whether cimetidine inhibited an expression of E-selectin on vascular endothelial cells by measuring E-selectin in plasma. We experienced one example that showed an interesting change of E-selectin and the quantity of E-selectin in plasma fell during the cimetidine dosage. However, we report that E-selectin has risen after the cimetidine dosage was cancelled in the cimetidine administrated group.

• Authors: Jin Kawase, Kenichi Kobayashi, Yoshihiro Imaeda, Syunji Umemoto, Sumio Matsumoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 11 Pg. 1578-9 (Oct 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 16315875 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• E-Selectin
• Cimetidine

Topics

• Cimetidine (pharmacology, therapeutic use)
• Colorectal Neoplasms (drug therapy)
• E-Selectin (analysis, blood)
• Endothelial Cells (chemistry)
• Humans
• Neoplastic Cells, Circulating (pathology)
• Stomach Neoplasms (drug therapy)