Claudin proteins in human cancer: promising new targets for diagnosis and therapy.

Abstract

The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.

• Authors: Patrice J Morin
• Journal: Cancer research (Cancer Res) Vol. 65 Issue 21 Pg. 9603-6 (Nov 01 2005) ISSN: 0008-5472 [Print] United States
• PMID: 16266975 (Publication Type: Journal Article, Review)

Chemical References

• CLDN3 protein, human
• CLDN4 protein, human
• Claudin-3
• Claudin-4
• Membrane Proteins

Topics

• Claudin-3
• Claudin-4
• Humans
• Membrane Proteins (biosynthesis, chemistry, metabolism)
• Neoplasms (diagnosis, metabolism, therapy)
• Tight Junctions (metabolism)