QT interval prolongation and torsade de pointes associated with indapamide.

Abstract

Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report.

• Authors: Konstantinos P Letsas, Ioannis P Alexanian, Loukas K Pappas, Stavros P Kounas, Michalis Efremidis, Antonios Sideris, Fotis Kardaras
• Journal: International journal of cardiology (Int J Cardiol) Vol. 112 Issue 3 Pg. 373-4 (Oct 10 2006) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 16260053 (Publication Type: Case Reports, Letter)

Chemical References

• Diuretics
• Indapamide

Topics

• Adult
• Diuretics (adverse effects)
• Electrocardiography
• Female
• Heart Conduction System (drug effects)
• Humans
• Hypertension (epidemiology)
• Indapamide (adverse effects)
• Lupus Erythematosus, Systemic (epidemiology)
• Torsades de Pointes (chemically induced)
• Ventricular Fibrillation (chemically induced)