Effect of amyloidosis on long-term survival in kidney transplantation.

Abstract

Amyloidosis is characterized by the accumulation of an amorphous material in various organs and tissues secondary to a variety of inflammatory, immune, infectious, and hereditary diseases. Since 1975, our transplantation team has performed 1470 renal transplantations. Between 1985 and July 2004, among 1159 kidney transplantations, 953 (82.3%) were from living donors and 206 (17.7%) from cadaveric donors. There were 32 recipients (28 men, 4 women; mean age, 31.4 +/- 1.7 years; range, 21 to 48 years) with amyloidosis, including, 28 (87.5%) who received grafts from living donors and 4 (12.5%) from cadaveric donors. Amyloidosis was secondary to familial Mediterranean fever in 22 (68.7%) patients and rheumatoid arthritis in 1 (3.1%). The remaining 9 (28.1%) patients had primary amyloidosis. The mean follow-up time was 51.2 +/- 5.7 months (range, 2-124 months). Mean HLA mismatch rate was 2.2 +/- 1. Twenty-six (81.2%) patients are alive at this time with functioning grafts, and a mean serum creatinine value of 2.1 +/- 1.5 ng/dL. The 1- and 5-year patient and graft survival rates were 90.6% and 84.3%, and 81.2% and 68.7%, respectively. We conclude that patients with amyloidosis may undergo kidney transplantation safely expecting outcomes similar to those patients who receive transplantations for other reasons.

• Authors: R Emiroglu, O Başaran, S Pehlivan, F N Ozdemir, T Colak, G Moray, T Noyan, M Haberal
• Journal: Transplantation proceedings (Transplant Proc) Vol. 37 Issue 7 Pg. 2967-8 (Sep 2005) ISSN: 0041-1345 [Print] United States
• PMID: 16213276 (Publication Type: Journal Article)

Topics

• Adult
• Amyloidosis (etiology, surgery)
• Familial Mediterranean Fever (complications)
• Female
• Follow-Up Studies
• Histocompatibility Testing
• Humans
• Kidney Transplantation (physiology)
• Living Donors
• Male
• Middle Aged
• Retrospective Studies
• Survivors
• Time Factors
• Tissue Donors