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Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate in cultured human lymphocytes.

Abstract
In our present study, different doses of allicin and L-ascorbic acid were tested against the genotoxic damage induced by chlormadinone acetate (CMA; 40 microM) using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as the parameters. Treatment with allicin and L-ascorbic acid resulted in reduction of CAs and SCEs. The results suggested a protective role of allicin and L-ascorbic acid against CMA induced genotoxic damage.
AuthorsYasir Hasan Siddique, Mohammad Afzal
JournalIndian journal of experimental biology (Indian J Exp Biol) Vol. 43 Issue 9 Pg. 769-72 (Sep 2005) ISSN: 0019-5189 [Print] India
PMID16187526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents
  • Disulfides
  • Free Radical Scavengers
  • Sulfinic Acids
  • Chlormadinone Acetate
  • allicin
  • Ascorbic Acid
Topics
  • Anti-Infective Agents (pharmacology)
  • Ascorbic Acid (pharmacology)
  • Cells, Cultured
  • Chlormadinone Acetate (pharmacology)
  • Chromosome Aberrations
  • Disulfides
  • Free Radical Scavengers (pharmacology)
  • Humans
  • Lymphocytes (cytology, drug effects)
  • Models, Chemical
  • Sister Chromatid Exchange
  • Sulfinic Acids (pharmacology)
  • Time Factors

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