4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study.

Abstract

The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e., 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case-control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladder, pharynx, larynx, oral cavity, leukemias, and chronic obstructive pulmonary disease or emphysema deaths). All individuals were never smokers or ex smokers for >10 years. 4-ABP-Hb adducts were analyzed in peripheral blood collected before the onset of the disease (median, 7 years). Overall, 4-ABP-Hb adducts were higher, although not statistically significantly so, in cases (as a whole) than controls. In the control population, high fruit and vegetable consumption significantly lowered the frequency of detectable adducts (Fisher's exact test, P = 0.025). Restricting the analysis to women, 4-ABP-Hb adducts were higher in cases than controls (Mann-Whitney P = 0.036) and the odds ratio (OR) for the presence/absence of adducts was 2.42 [95% confidence interval (95% CI), 1.18-4.98]. Moreover, the association of adducts with the individual cancer types was stronger in women than in the whole study population, although statistically significant only for leukemias (OR, 2.77; 95% CI, 1.06-7.20). The results provide some evidence that women may be more susceptible to environmental tobacco smoke, as suggested by their higher adduct levels. The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure.

• Authors: Luisa Airoldi, Paolo Vineis, Alessandro Colombi, Luca Olgiati, Carlo Dell'Osta, Roberto Fanelli, Luca Manzi, Fabrizio Veglia, Herman Autrup, Alison Dunning, Seymour Garte, Pierre Hainaut, Gerard Hoek, Michal Krzyzanowski, Christian Malaveille, Giuseppe Matullo, Kim Overvad, Anne Tjonneland, Francoise Clavel-Chapelon, Jakob Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Marco Peluso, Vittorio Krogh, Rosario Tumino, Salvatore Panico, Hendrik B Bueno-De-Mesquita, Petra H Peeters, Eiliv Lund, Antonio Agudo, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, M Dolores Chirlaque, Josè R Quiros, Goran Berglund, Bengt Järvholm, Goran Hallmans, Nicholas E Day, Naomi Allen, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 14 Issue 9 Pg. 2118-24 (Sep 2005) ISSN: 1055-9965 [Print] United States
• PMID: 16172219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Hemoglobins
• Tobacco Smoke Pollution
• hemoglobin, 4-aminobiphenyl-

Topics

• Biomarkers (analysis)
• Case-Control Studies
• Female
• Hemoglobins (analysis)
• Humans
• Male
• Middle Aged
• Neoplasms (etiology)
• Prospective Studies
• Risk Factors
• Sex Factors
• Smoking (adverse effects)
• Tobacco Smoke Pollution (adverse effects)