[An experiment study of protection and treatment of Kudan granule on rats of pulmonary fibrosis induced by pinyangmycin].

Abstract

OBJECTIVE:

To explore the protection and treatment effects of Kudan granule on rats of pulmonary fibrosis induced by pinyangmycin.

METHOD:

In asepsis condition, rat was anaesthetized by 3.5% chloral hydrate, inserted the needle above the bifurcation of trachea and injecting 5 mg x kg(-1) pinyangmycin normal saline solution.

RESULT:

For model-group rats, after injecting pinyangmycin at 7, 14, 28, 56 days, there were mass inflammation cell infiltration at pulmonary alveoli and interstitial, the pulmonary alveolar wall and interstitial thickened obviously, and the pulmonary interval broadened distinctly. The structure of collagen fiber was destroyed, and the pulmonary alveoli disappeared. By Masson dyeing, there were hunk collagen fiber and the consolidation of lung had come into being. Compared with the model group, the rats of Kudan granule big-dose group, at 7, 14, 28, 56 days after injecting pinyangmycin, there were still much inflammation cell infiltration at pulmonary alveoli and interstitial, pulmonary interstitial edema and spotty necrosis, thickened alveolar wall, broadened pulmonary interval, and much collagen fiber in pulmonary interstitial, but there was not bunk the consolidation of lung. The curative effect of Kudan granule small-dose group was not better than that of Kudan granule big-dose group, because there were still bunk collagen fiber and the consolidation of lung in pulmonary interstitial. Although the destroyed area was more than 50%, it was better than that of the model-group.

CONCLUSION:

The big-dose Kudan granule show the better function of protection and treatment for pulmonary fibrosis of rats induced by pinyangmycin.

• Authors: Chong-shun Song, Ying Ren, Jun-xiang Yin, Hai-yun Sun, Jing-jing Song, Jie-feng Cui, Wei Tan, Jing Guo, Xin Dai, Feng-zhi Zhao, Jin-duo Yang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 30 Issue 13 Pg. 1013-6 (Jul 2005) ISSN: 1001-5302 [Print] China
• PMID: 16161432 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• Bleomycin
• zhengguangmycin

Topics

• Animals
• Bleomycin (analogs & derivatives)
• Dose-Response Relationship, Drug
• Drug Combinations
• Drugs, Chinese Herbal (administration & dosage, isolation & purification, therapeutic use)
• Female
• Lung (pathology)
• Male
• Phytotherapy
• Plants, Medicinal (chemistry)
• Pulmonary Fibrosis (chemically induced, drug therapy, pathology)
• Random Allocation
• Rats
• Rats, Wistar
• Salvia miltiorrhiza (chemistry)
• Scutellaria baicalensis (chemistry)
• Sophora (chemistry)