[Effects of Chansu injection on transplanting-tumor models S180 in mice and human colon cancer HT-29 in nude mice].

Abstract

OBJECTIVE:

To study the antitumor effects of Chansu injection on transplanting- tumor of S(180 ) in mice and human colon cancer HT-29 in nude mice.

METHODS:

Using transplanting- tumor models of S(180 ) in mice and human colon cancer HT-29 in nude mice,the tumor inhibitive ratio(IR) of Chansu injection was determined and apoptosis was microscopically observed.

RESULTS:

Compared with tumor-negative control groups, IR at different dosage of Chansu in models of S(180) and HT-29 was 19.1% - 38.2% and 9.5% - 15.8% respectively,there was a dose-dependent relationship in models of S ( 180) (P< 0.05) and HT- 29 (P> 0.05). The tumor growth was markedly inhibited by cyclophosphamide (CTX) in model of S( 180) with IR of 70.7% and in model of HT-29 with IR of 67.1%, compared with control groups, both P< 0.01; apoptosis induced by CTX was markedly observed by in microscope examination. No significant side effects were shown in the study group.

CONCLUSIONS:

Chansu injection can significantly inhibit tumor growth in model of S(180), but not in model of HT- 29. Different type of tumor has different drug-sensitivity.

• Authors: Zhen-huai Yang, Yong-ju Liang, Jie-wen Guo, Jing-qiang Pan, Yan Ding, Guan-ning Li
• Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery (Zhonghua Wei Chang Wai Ke Za Zhi) Vol. 8 Issue 2 Pg. 169-71 (Mar 2005) ISSN: 1671-0274 [Print] China
• PMID: 16155834 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bufanolides
• Drugs, Chinese Herbal
• chan su

Topics

• Animals
• Bufanolides (pharmacology)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• HT29 Cells
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred Strains
• Mice, Nude
• Sarcoma 180 (drug therapy)
• Xenograft Model Antitumor Assays