Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.

Abstract

The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.

• Authors: R O'Hara, C M Schröder, H C Kraemer, N Kryla, C Cao, E Miller, A F Schatzberg, J A Yesavage, G M Murphy Jr
• Journal: Neurology (Neurology) Vol. 65 Issue 4 Pg. 642-4 (Aug 23 2005) ISSN: 1526-632X [Electronic] United States
• PMID: 16116137 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Apolipoprotein E4
• Apolipoproteins E

Topics

• Aged
• Apolipoprotein E4
• Apolipoproteins E (genetics)
• Brain (metabolism, physiopathology)
• Cognition Disorders (genetics, physiopathology)
• DNA Mutational Analysis
• Disease Progression
• Female
• Genetic Predisposition to Disease (genetics)
• Genetic Testing
• Genetic Variation (genetics)
• Heterozygote
• Humans
• Male
• Memory Disorders (genetics, physiopathology, psychology)
• Middle Aged
• Neuropsychological Tests
• Oxidative Stress (genetics)
• Sleep Apnea Syndromes (complications, genetics, physiopathology)
• Sleep Stages (genetics)