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Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform.

Abstract
A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki-Heck-type arylation, a Liebeskind-Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.
AuthorsNobuhiro Muraoka, Masahiro Mineno, Kenichiro Itami, Jun-ichi Yoshida
JournalThe Journal of organic chemistry (J Org Chem) Vol. 70 Issue 17 Pg. 6933-6 (Aug 19 2005) ISSN: 0022-3263 [Print] United States
PMID16095319 (Publication Type: Journal Article)

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