Abstract |
A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki-Heck-type arylation, a Liebeskind-Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.
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Authors | Nobuhiro Muraoka, Masahiro Mineno, Kenichiro Itami, Jun-ichi Yoshida |
Journal | The Journal of organic chemistry
(J Org Chem)
Vol. 70
Issue 17
Pg. 6933-6
(Aug 19 2005)
ISSN: 0022-3263 [Print] United States |
PMID | 16095319
(Publication Type: Journal Article)
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