Abstract | BACKGROUND AND OBJECTIVE: METHODS AND RESULTS: Functional TAFI levels, defined as TAFI-related retardation (RT), the difference in clot lysis time (LT) in the absence or presence of a specific activated TAFI inhibitor (potato carboxypeptidase inhibitor [PCI]), were higher in patients than controls (19.5 +/- 4.2 vs. 17.7 +/- 3.7 min, P < 0.005). Clot LTs in the presence of PCI, which were independent of TAFI, were also increased in ischemic stroke patients. This indicates that in these patients fibrinolysis is impaired not only by high TAFI levels, but also by other mechanisms. Individuals with functional TAFI levels in the highest quartile had an increased risk of ischemic stroke compared with the lowest quartile [odds ratio (OR) 4.0, 95% confidence interval (CI): 1.6-9.8]. In an unselected group of 36 of the 125 stroke patients functional TAFI levels were also measured at 3 months, and were persistently high. This indicates that increased functional TAFI levels after stroke are not caused by an acute phase reaction. No difference was found between patients and controls with respect to TAFI genotype distribution. CONCLUSIONS: Increased functional TAFI levels, resulting in decreased fibrinolysis, are associated with an increased risk of ischemic stroke.
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Authors | F W G Leebeek, M P J Goor, A H C Guimaraes, G-J Brouwers, M P M Maat, D W J Dippel, D C Rijken |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 3
Issue 10
Pg. 2211-8
(Oct 2005)
ISSN: 1538-7933 [Print] England |
PMID | 16092924
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Brain Ischemia
(epidemiology, etiology)
- Carboxypeptidase B2
(blood, genetics, physiology)
- Case-Control Studies
- Europe
- Female
- Fibrinolysis
- Genotype
- Humans
- Kinetics
- Male
- Middle Aged
- Molecular Epidemiology
- Polymorphism, Genetic
- Prospective Studies
- Risk
- Stroke
(epidemiology, etiology)
- White People
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