Green tea polyphenol extract attenuates colon injury induced by experimental colitis.

Abstract	Inflammatory bowel disease (IBD) is characterised by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of the present study was to examine the effects of green tea extract in rats subjected to experimental colitis induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). At 4 days after DNBS administration the rats were sacrificed. Treatment with green tea extract significantly attenuated diarrhoea and loss of body weight. This was associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of colonic myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-alpha) production. Green tea extract also reduced the appearance of nitrotyrosine immunoreactivity in the colon and reduced the up-regulation of ICAM-1.
Authors	Emanuela Mazzon, Carmelo Muià, Rosanna Di Paola, Tiziana Genovese, Marta Menegazzi, Angelina De Sarro, Hisanori Suzuki, Salvatore Cuzzocrea
Journal	Free radical research (Free Radic Res) Vol. 39 Issue 9 Pg. 1017-25 (Sep 2005) ISSN: 1071-5762 [Print] England
PMID	16087483 (Publication Type: Comparative Study, Journal Article)
Chemical References	Benzenesulfonates Flavonoids Phenols Polyphenols Tea Tumor Necrosis Factor-alpha dinitrobenzenesulfonic acid Intercellular Adhesion Molecule-1 3-nitrotyrosine Tyrosine Peroxidase Heme Oxygenase (Decyclizing)
Topics	Animals Benzenesulfonates Chromatography, High Pressure Liquid Colitis (chemically induced, drug therapy, pathology, prevention & control) Colon (drug effects, pathology) Flavonoids (analysis, isolation & purification, therapeutic use) Heme Oxygenase (Decyclizing) (analysis) Immunohistochemistry Intercellular Adhesion Molecule-1 (analysis) Male Peroxidase (metabolism) Phenols (analysis, isolation & purification, therapeutic use) Phytotherapy Plant Leaves (chemistry) Polyphenols Rats Rats, Sprague-Dawley Tea (chemistry) Tumor Necrosis Factor-alpha (metabolism) Tyrosine (analogs & derivatives, analysis)

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