Effects of a high-cholesterol diet on cell behavior in rat periodontitis.

Abstract

Studies have shown an association between periodontitis and serum cholesterol levels. We hypothesized that high dietary cholesterol could influence periodontitis as a result of proliferation of the junctional epithelium. Rats were divided into 4 groups. Two groups were fed a regular diet, and 2 groups were fed a high-cholesterol diet. One of each dietary group was treated with periodontitis-inducing agents (lipopolysaccharide and proteases), while the other was treated with pyrogen-free water. Feeding rats with a high-cholesterol diet induced an increase in blood total cholesterol and a decrease in high-density lipoprotein cholesterol. Proliferation of the junctional epithelium with increasing bone resorption was promoted by the consumption of a high-cholesterol diet. High dietary cholesterol further increased the cell-proliferative activity of the junctional epithelium induced by lipopolysaccharide and proteases. These results suggest that high dietary cholesterol can initiate and augment periodontitis in the rat periodontitis model.

• Authors: T Tomofuji, H Kusano, T Azuma, D Ekuni, T Yamamoto, T Watanabe
• Journal: Journal of dental research (J Dent Res) Vol. 84 Issue 8 Pg. 752-6 (Aug 2005) ISSN: 0022-0345 [Print] United States
• PMID: 16040735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, Dietary
• Proliferating Cell Nuclear Antigen
• Triglycerides
• Cholesterol

Topics

• Alveolar Bone Loss (etiology)
• Analysis of Variance
• Animals
• Cell Proliferation
• Cholesterol (blood)
• Cholesterol, Dietary (adverse effects)
• DNA Fragmentation
• Epithelial Attachment (cytology, drug effects)
• In Situ Nick-End Labeling
• Male
• Periodontitis (blood, etiology)
• Proliferating Cell Nuclear Antigen (analysis)
• Rats
• Rats, Wistar
• Statistics, Nonparametric
• Triglycerides (blood)