Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era.

Abstract

OBJECTIVE:

The insulin-like growth factor (IGF) axis is thought to contribute to the growth and progression of prostate cancer. Some prospective studies support a direct association between IGF-1 and prostate cancer, in particular advanced disease, whereas both inverse and direct associations with prostate cancer have been reported for insulin-like growth factor binding protein-3 (IGFBP-3), the major IGF-1 binding protein in circulation. We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era.

METHODS:

We identified 462 prostate cancer cases diagnosed after providing a blood specimen in 1993, but before January 1998 among men in the Health Professionals Follow-up Study. Controls were 462 age-matched men without prostate cancer who had had a PSA test after providing a blood specimen. We measured plasma concentrations of IGF-1 and IGFBP-3 by ELISA. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of prostate cancer.

RESULTS:

Men with higher concentrations of IGF-1 (comparing extreme quartiles OR=1.37, 95% CI 0.92-2.03, p-trend=0.05) and IGFBP-3 (OR=1.62, 95% CI 1.07-2.46, p-trend=0.08) had a higher risk of prostate cancer. After mutual statistical adjustment, these associations were attenuated for both IGF-1 (OR=1.17, 95% CI 0.69-1.99, p-trend=0.29) and IGFBP-3 (OR=1.40, 95% CI 0.80-2.44, p-trend=0.56). We found no significant association of IGF-1 with regionally invasive or metastatic (>/=T3b, N1, or M1) prostate cancer, although the number of these cases was small (n=42).

CONCLUSIONS:

Our findings for IGF-1 and prostate cancer diagnosed in the PSA era are similar to most previous studies, albeit weaker in magnitude. Our suggestive positive findings for IGFBP-3 are similar to some studies, but in direct contrast to others.

• Authors: Elizabeth A Platz, Michael N Pollak, Michael F Leitzmann, Meir J Stampfer, Walter C Willett, Edward Giovannucci
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 16 Issue 3 Pg. 255-62 (Apr 2005) ISSN: 0957-5243 [Print] Netherlands
• PMID: 15947877 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers, Tumor
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor I
• Prostate-Specific Antigen

Topics

• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Case-Control Studies
• Enzyme-Linked Immunosorbent Assay
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (analysis)
• Male
• Middle Aged
• Predictive Value of Tests
• Prospective Studies
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (etiology, pathology)
• Risk Factors
• Sensitivity and Specificity