Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs.

Abstract

The S3Pvac synthetic vaccine composed of three peptides (GK1, KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization. Herein, clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains, with a concomitant reduction in the antibody levels. Thus, S3Pvac represents a powerful means of controlling cysticercosis infection in pigs.

• Authors: Aline S de Aluja, Nelly M Villalobos, Gabriela Nava, Andrea Toledo, José Juan Martínez, Agustín Plancarte, Luis Felipe Rodarte, Gladis Fragoso, Edda Sciutto
• Journal: Vaccine (Vaccine) Vol. 23 Issue 31 Pg. 4062-9 (Jul 01 2005) ISSN: 0264-410X [Print] Netherlands
• PMID: 15927324 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Helminth
• Vaccines, Subunit
• Vaccines, Synthetic

Topics

• Animals
• Antibodies, Helminth (blood)
• Cricetinae
• Cysticercosis (pathology, prevention & control, veterinary)
• Enzyme-Linked Immunosorbent Assay
• Female
• Leukocytes, Mononuclear (immunology)
• Male
• Muscles (parasitology)
• Swine
• Swine Diseases (prevention & control)
• Taenia solium (immunology)
• Vaccines, Subunit (administration & dosage, immunology)
• Vaccines, Synthetic (administration & dosage, immunology)