Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.

Abstract

In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.

• Authors: Ilse Jacobsen, Jörg Gerstenberger, Achim D Gruber, Janine T Bossé, Paul R Langford, Isabel Hennig-Pauka, Jochen Meens, Gerald-F Gerlach
• Journal: Infection and immunity (Infect Immun) Vol. 73 Issue 6 Pg. 3740-4 (Jun 2005) ISSN: 0019-9567 [Print] United States
• PMID: 15908404 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Bacterial Proteins
• Repressor Proteins
• Transferrin-Binding Protein B
• ferric uptake regulating proteins, bacterial
• Iron

Topics

• Actinobacillus Infections (metabolism, pathology)
• Actinobacillus pleuropneumoniae (growth & development, pathogenicity)
• Animals
• Bacterial Proteins (physiology)
• Iron (metabolism)
• Lung (pathology)
• Repressor Proteins (physiology)
• Swine
• Transferrin-Binding Protein B (genetics)
• Virulence