A triclosan-containing compomer reduces Lactobacillus spp. predominant in advanced carious lesions.

Abstract

OBJECTIVES:

To assess the antimicrobial effect of acid etching or a triclosan-containing compomer on the cultivable microflora of incompletely excavated dentinal carious lesions.

METHODS:

Thirty detinal lesions were opened with a diamond burr. Subsequent to removal of the softened biomass a sample of dentin was taken from the cavity floor with a round bur. Ten cavities each were treated with 36% phosphoric acid (PH) for 15s, covered with a triclosan-containing compomer (TC) or received no treatment as control (CO). All lesions were restored with a compomer composite. Sampling was performed directly after etching in the PH group and at re-entry after 6 weeks in all groups. Aliquots were plated on blood agar and selective media for Lactobacilli (Rogosa) and mutans Streptococci (MSB). Cultures were incubated anaerobically for 7 days at 37 degrees C prior to quantitative assessment and biotyping of the isolates.

RESULTS:

Application of phosphoric acid resulted in initial reduction of the totally cultivable microflora (p=0.006). Evaluation of the total number of cultivable microflora after 6 weeks revealed no differences between the groups (p>0.05). Lactobacilli counts were significantly lower in the TC group compared to the PH and CO groups (p<0.05). No difference was detected between the PH and CO groups after 6 weeks.

SIGNIFICANCE:

Phosphoric acid initially reduces the number of microorganisms in carious dentin but not in the longer term. The experimental triclosan composite suppresses Lactobacilli species over a period of 6 weeks.

• Authors: Michael J Wicht, Rainer Haak, Susanne Kneist, Michael J Noack
• Journal: Dental materials : official publication of the Academy of Dental Materials (Dent Mater) Vol. 21 Issue 9 Pg. 831-6 (Sep 2005) ISSN: 0109-5641 [Print] England
• PMID: 15876453 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Compomers
• Composite Resins
• Dyract
• Phosphoric Acids
• Polymethacrylic Acids
• Prime and Bond NT
• Triclosan
• phosphoric acid

Topics

• Acid Etching, Dental
• Actinomyces (drug effects)
• Adult
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Colony Count, Microbial
• Compomers (chemistry)
• Composite Resins (chemistry)
• Dental Caries (microbiology, therapy)
• Dental Restoration, Permanent
• Dentin (microbiology)
• Female
• Follow-Up Studies
• Humans
• Lactobacillus (drug effects)
• Male
• Phosphoric Acids (pharmacology)
• Polymethacrylic Acids (chemistry)
• Streptococcus (drug effects)
• Triclosan (administration & dosage, therapeutic use)