Abstract |
The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50, and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L3-L4 stages of A caninum (36 hours after inoculation), greater than 80% against L4 (120 hours after inoculation) and early L5 stages (216 hours after inoculation), and greater than 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs.
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Authors | B L Blagburn, C M Hendrix, D S Lindsay, J L Vaughan, D I Hepler, J C Wright |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 53
Issue 4
Pg. 513-6
(Apr 1992)
ISSN: 0002-9645 [Print] United States |
PMID | 1586020
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthelmintics
- Anti-Bacterial Agents
- Macrolides
- moxidectin
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Topics |
- Ancylostomiasis
(drug therapy, veterinary)
- Animals
- Anthelmintics
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Dog Diseases
(drug therapy)
- Dogs
- Feces
(parasitology)
- Female
- Intestinal Diseases, Parasitic
(drug therapy, veterinary)
- Macrolides
- Male
- Parasite Egg Count
(veterinary)
- Trichuriasis
(drug therapy, veterinary)
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