[The effect of early fluvastatin therapy on inflammatory factors in acute coronary syndrome].

Abstract

OBJECTIVE:

To investigate the effects of different doses of fluvastatin on serum levels of high-sensitive C-reactive protein (hs-CRP) and tumour necrosis factor-alpha (TNFalpha) in the early phase of acute coronary syndrome (ACS).

METHODS:

Fifty eight patients with ACS were randomly separated into three groups. 20 patients in group A were given routine therapy, 20 patients in group B were given routine therapy with oral fluvastatin 40 mg once daily for 1 week and 18 patients in group C received routine therapy with oral fluvastatin 80 mg once daily for 1 week. 20 patients with stable coronary heart disease served controls. The serum levels of hs-CRP and TNFalpha before and after therapy were measured with immunoturbidimetric assay and ELISA method.

RESULTS:

(1) The serum levels of hs-CRP and TNFalpha in the patients with ACS were significantly higher than those in the control group (P < 0.05). (2) The serum levels of hs-CRP and TNFalpha significantly lowered after one week of therapy in the two fluvastatin treated groups (P < 0.01 in all), especially in the 80 mg fluvastatin group, while no significant difference was observed before and after treatment in the routine therapy group. (3) The serum levels of hs-CRP and TNFalpha had a significant positive correlation in the patients with ACS (r = 0.70, P < 0.01), but no relationship were observed between TC, TG, LDL-C, or HDL-C and hs-CRP or TNFalpha by Pearson correlation analysis.

CONCLUSIONS:

The serum levels of inflammatory factors including CRP and TNFalpha are increased in patients with ACS and early fluvastatin intervention may decease dose-dependently the serum levels of hs-CRP and TNFalpha. The anti-inflammatory effect of fluvastatin may be beyond that of lipid lowering. Early intensive fluvastatin treatment may yield more significant benefits in the patients with ACS.

• Authors: Jun Yang, Xiang-ping Li, Shui-ping Zhao, Jiang Li, Jing-dong Li, Xiao-ming Xie, Jun Peng
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 44 Issue 3 Pg. 184-7 (Mar 2005) ISSN: 0578-1426 [Print] China
• PMID: 15840256 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anticholesteremic Agents
• Fatty Acids, Monounsaturated
• Indoles
• Lipids
• Tumor Necrosis Factor-alpha
• Fluvastatin
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Anticholesteremic Agents (administration & dosage)
• C-Reactive Protein (metabolism)
• Coronary Disease (blood, drug therapy)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Fatty Acids, Monounsaturated (administration & dosage)
• Female
• Fluvastatin
• Humans
• Indoles (administration & dosage)
• Inflammation (blood)
• Lipids (blood)
• Male
• Middle Aged
• Tumor Necrosis Factor-alpha (metabolism)