[Therapeutic intensification and autologous stem cell transplantation in autoimmune diseases].

Abstract	THE PATHOPHYSIOLOGY of most autoimmune diseases is often poorly understood. EXPERIMENTAL CONSIDERATIONS and clinical experience suggest that high doses immunoablation followed by stem cell transplantation is a therapeutic option to consider for certain severe autoimmune disorders. THE CONCEPT OF RESTORING NORMAL IMMUNE REACTIVITY must in part br true since current results of 466 transplants (445 autologous, 21 allogeneic) patients suffering from various autoimmune diseases show a beneficial outcome in approximately 2/3 of the patients. TO IMPROVE THE EFFICACY AND SAFETY OF SUCH AN AGGRESSIVE PROCEDURE in patients with potentially affected vital organs by the underlying autoimmune disease, it is especially important to follow international consensus guidelines and to centrally collect clinical data for in depth analysis in the EBMT International Stem Cell Project for Autoimmune Disease in Basel, Switzerland. PHASE III STUDIES ARE RUNNING FOR SYSTEMIC SCLEROSIS (Astis, Autologous Stem cell Transplantation International Rheumatoid Arthritis Trial) started in 2003. A STUDY PROJECT IS PLANNED FOR MULTIPLE SCLEROSIS (Astims, Autologous Stem cell Transplantation International Multiple Sclerosis).
Authors	Z Marjanovic, I Gerber, C Toledano, J Hen-Solal, R Damade, I de Saint-Cyr, F Sarrot-Reynauld, D Ilié, M Daneshpouy, N Mounier, M Ruivard, C Tyndall, E Vidal, I Quere, J-M Durand, J Constans, D Farge
Journal	Presse medicale (Paris, France : 1983) (Presse Med) Vol. 34 Issue 4 Pg. 311-8 (Feb 26 2005) ISSN: 0755-4982 [Print] France
Vernacular Title	Intensification thérapeutique et autogreffe de cellules souches hématopoïétiques pour le traitement des maladies auto-immunes.
PMID	15798553 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)
Topics	Adolescent Adult Age Factors Aged Animals Autoimmune Diseases (immunology, therapy) Child Child, Preschool Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Disease Models, Animal Feasibility Studies Humans Infant Mice Middle Aged Patient Selection Prospective Studies Randomized Controlled Trials as Topic Registries Stem Cell Transplantation Transplantation, Autologous Transplantation, Homologous Treatment Outcome

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