Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.

Abstract

BACKGROUND:

Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium.

METHODS:

The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry.

RESULTS:

In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma.

CONCLUSION:

Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.

• Authors: Keiichi Tozawa, Takashi Okamoto, Noriyasu Kawai, Yoshihiro Hashimoto, Yutaro Hayashi, Kenjiro Kohri
• Journal: Kidney international (Kidney Int) Vol. 67 Issue 4 Pg. 1391-6 (Apr 2005) ISSN: 0085-2538 [Print] United States
• PMID: 15780091 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Lewis Blood Group Antigens
• Oligosaccharides
• Sialyl Lewis X Antigen
• Cimetidine

Topics

• Adjuvants, Immunologic (therapeutic use)
• Carcinoma, Renal Cell (pathology)
• Cimetidine (therapeutic use)
• Humans
• Immunohistochemistry
• Kidney Neoplasms (pathology)
• Lewis Blood Group Antigens
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Oligosaccharides (analysis)
• Sialyl Lewis X Antigen