[Application of mesenchymal stem cell in immunotherapy--review].

Abstract

There has been an increasing interest in recent years on mesenchymal stem cell (MSC). It is well known that MSCs are capable of self-renewal and differentiating into many cell lineages. MSC can be expended to a large quantity that is required for clinical transplantation. Recent studies show that MSC have potential application in immune diseases due to their unique immunologic characteristics, such as low immunogenicity and immunoregulatory function. But their immunoregulatory mechanism is not yet clear. This review discusses the advances in researches on the mechanism of MSCs' immunoregulatory function and potential clinical application in immune disease and organ transplantation.

• Authors: Lian-Ming Liao, Qin Han, Chun-Hua Zhao
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 13 Issue 1 Pg. 158-63 (Feb 2005) ISSN: 1009-2137 [Print] China
• PMID: 15748459 (Publication Type: Journal Article, Review)

Topics

• Animals
• B-Lymphocytes (immunology)
• Graft vs Host Disease (immunology)
• Humans
• Immune Tolerance (immunology)
• Immunotherapy
• Mesenchymal Stem Cell Transplantation (methods)
• Mesenchymal Stem Cells (cytology, immunology)
• T-Lymphocytes (immunology)