Abstract | PURPOSE: METHODS: We conducted a retrospective analysis using a large US health insurance claims database to estimate the incidence and costs of treatment of SREs in patients with bone metastases of lung cancer treated in a naturalistic setting. Study subjects had >/=2 encounters with a diagnosis of primary lung cancer and >/=2 encounters with a diagnosis of metastases to bone. SREs were identified based on the occurrence on or after the date of first diagnosis of bone metastases, of (1) >/=1 encounter with a diagnosis of pathological fracture, spinal cord compression or hypercalcemia, (2) >/=1 bone surgery or radiotherapy procedure, or (3) the initiation of opioid analgesic therapy. Survival and costs of SRE-related care in patients with SREs were estimated using Kaplan-Meier methods. RESULTS: We identified 534 patients with lung cancer and bone metastases, including 295 (55%) with >/=1 SRE. Radiotherapy (68%) and fracture (35%) were the most common SREs. Median survival after the first identified SRE was 4.1 months (95% confidence interval: 3.6-5.5 months). The estimated lifetime SRE-related cost per patient was USD 11,979 (95% confidence interval: USD 10,193-13,766). Radiotherapy accounted for the greatest proportion of cost (61%) by SRE type. CONCLUSION:
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Authors | Thomas Delea, Corey Langer, James McKiernan, Martin Liss, John Edelsberg, Jane Brandman, Jennifer Sung, Monika Raut, Gerry Oster |
Journal | Oncology
(Oncology)
Vol. 67
Issue 5-6
Pg. 390-6
( 2004)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 15713995
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2004 S. Karger AG, Basel |
Chemical References |
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Topics |
- Aged
- Analgesics
(economics)
- Bone Neoplasms
(complications, economics, radiotherapy, secondary)
- Cost-Benefit Analysis
- Female
- Fractures, Spontaneous
(economics, etiology, therapy)
- Health Care Costs
- Humans
- Hypercalcemia
(economics, etiology, therapy)
- Lung Neoplasms
(pathology)
- Male
- Middle Aged
- Pain
(economics, etiology)
- Pain Management
- Radiotherapy
(economics)
- Retrospective Studies
- Spinal Cord Compression
(economics, etiology, therapy)
- Survival Analysis
- United States
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