Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression.

Abstract

BACKGROUND:

Over-expression of the oncogene c-Myc has been implicated in the development and progression of human prostate carcinoma. However, previous assessments of c-Myc expression have not revealed its potential for predicting prostate carcinoma progression. Caveolin-1 is associated with prostate carcinoma progression and is a downstream target gene of c-Myc. The observation that caveolin-1 can suppress c-Myc-induced apoptosis suggested the potential for cooperation between c-Myc and caveolin-1 in malignant progression. In this study, the authors evaluated the prognostic potential of combined c-Myc and caveolin-1 expression in human prostate carcinoma progression.

METHODS:

Immunostaining with c-Myc and caveolin-1-specific antibodies was performed on paraffin sections from 104 radical prostatectomy specimens from men with lymph node negative prostate carcinoma. Combined c-Myc and caveolin-1 immunostaining scores were related with the clinical and pathologic features and the probability of prostate-specific antigen recurrence after surgery.

RESULTS:

The combination of c-Myc and caveolin-1 immunopositivity correlated positively with Gleason score (rho = 0.219; P = 0.0253) and positive surgical margin (rho = 0.333; P = 0.0006). The combination of positive c-Myc and caveolin-1 in patients with clinically confined prostate carcinoma was a significant prognostic marker for the time to disease progression after surgery in both univariate analysis (P = 0.0039; hazard ratio, 3.035) and multivariate analysis (P = 0.0114; hazard ratio, 2.916).

CONCLUSIONS:

The coexpression of c-Myc and caveolin-1 showed potential as a useful prognostic marker for human prostate carcinoma. The current results suggest interactions between c-Myc and caveolin-1 in the progression of human prostate carcinoma.

• Authors: Guang Yang, Terry L Timme, Anna Frolov, Thomas M Wheeler, Timothy C Thompson
• Journal: Cancer (Cancer) Vol. 103 Issue 6 Pg. 1186-94 (Mar 15 2005) ISSN: 0008-543X [Print] United States
• PMID: 15712208 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers, Tumor
• CAV1 protein, human
• Caveolin 1
• Caveolins
• Proto-Oncogene Proteins c-myc

Topics

• Adenocarcinoma (pathology, surgery)
• Age Distribution
• Aged
• Biomarkers, Tumor (metabolism)
• Biopsy, Needle
• Caveolin 1
• Caveolins (analysis)
• Cohort Studies
• Confidence Intervals
• Disease Progression
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Predictive Value of Tests
• Probability
• Prognosis
• Proportional Hazards Models
• Prostatectomy (methods)
• Prostatic Neoplasms (mortality, pathology, surgery)
• Proto-Oncogene Proteins c-myc (metabolism)
• Risk Assessment
• Sensitivity and Specificity
• Survival Analysis
• Tissue Culture Techniques
• Treatment Outcome