Prolonged paralysis related to mivacurium: a case study.

Abstract

Pseudocholinesterase deficiency is usually identified when an anesthetized patient has prolonged paralysis after receiving neuromuscular blocking agents dependent on pseudocholinesterase enzymes for hydrolysis. This rare complication, most frequently associated with succinylcholine, can occur with the use of mivacurium, one of the newer nondepolarizing muscle relaxants also hydrolyzed by pseudocholinesterase. Prolonged paralysis has occurred 3 times in the past 2 years at this pediatric hospital after administration of mivacurium. The following case study describes causality and interventions for a patient with prolonged paralysis after receiving mivacurium.

• Authors: Kathy Kendrick
• Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses (J Perianesth Nurs) Vol. 20 Issue 1 Pg. 7-12 (Feb 2005) ISSN: 1089-9472 [Print] United States
• PMID: 15688329 (Publication Type: Case Reports, Journal Article)

Chemical References

• Isoquinolines
• Neuromuscular Nondepolarizing Agents
• Mivacurium
• Butyrylcholinesterase

Topics

• Adolescent
• Butyrylcholinesterase (deficiency)
• Cerebral Palsy (complications)
• Female
• Humans
• Isoquinolines (adverse effects)
• Mivacurium
• Neuromuscular Nondepolarizing Agents (adverse effects)
• Paralysis (chemically induced, nursing)
• Postanesthesia Nursing
• Postoperative Complications (chemically induced, nursing)