Abstract | BACKGROUND: METHODS: During halothane anesthesia, a hind paw plantar incision was performed in rats receiving four fentanyl subcutaneous injections (100 microg/kg per injection, every 15 min). In some groups, three subcutaneous ketamine injections (10 mg/kg per injection, every 5 h) were performed in saline- or fentanyl-treated rats. One day after surgery, the analgesic effect of morphine (2 mg/kg subcutaneous) was tested. Analgesia, mechanical hyperalgesia, tactile allodynia, and pain score were assessed for several days using the paw pressure vocalization test, the von Frey application test, and the postural disequilibrium test. RESULTS: CONCLUSIONS:
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Authors | Philippe Richebé, Cyril Rivat, Jean-Paul Laulin, Pierre Maurette, Guy Simonnet |
Journal | Anesthesiology
(Anesthesiology)
Vol. 102
Issue 2
Pg. 421-8
(Feb 2005)
ISSN: 0003-3022 [Print] United States |
PMID | 15681961
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Disease Models, Animal
- Drug Synergism
- Fentanyl
(therapeutic use)
- Hindlimb
- Ketamine
(therapeutic use)
- Male
- Pain, Postoperative
(drug therapy, physiopathology)
- Perioperative Care
(methods)
- Rats
- Rats, Sprague-Dawley
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