Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder.

Abstract

OBJECTIVE:

To evaluate whether polymorphism of the interleukin-4 gene exon 3, and of the interleukin-1beta gene exon 5 and promoter region, are associated with transitional cell carcinoma (TCC) of the urinary bladder, as cytokines are hypothesized to be important in cancer formation.

PATIENTS, SUBJECTS AND METHODS:

The study included 138 patients with TCC of urinary bladder and 105 healthy controls living in the same area. Each genetic polymorphism was typed using polymerase chain reaction-based restriction analysis. Genotype distribution and allelic frequencies between patients and controls were compared.

RESULTS:

There were significant differences in genotype and allelic distribution of intron 3 RP1/RP2 polymorphism (P < 0.001), but no significant difference in genotype distribution or allelic frequencies of the interleukin-1beta gene polymorphism between patients with bladder cancer and controls.

CONCLUSION:

The interleukin-4 gene intron 3 polymorphism is associated with bladder cancer and is a potential genetic marker in screening for the possible causes of bladder cancer.

• Authors: Fuu-Jen Tsai, Chao-Hsiang Chang, Chang-Chung Chen, Te-Chun Hsia, Huey-Yi Chen, Wen-Chi Chen
• Journal: BJU international (BJU Int) Vol. 95 Issue 3 Pg. 432-5 (Feb 2005) ISSN: 1464-4096 [Print] England
• PMID: 15679809 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1
• Interleukin-4

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Transitional Cell (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-1 (genetics)
• Interleukin-4 (genetics)
• Introns (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Urinary Bladder Neoplasms (genetics)