[Expression of telomerase activity and c-myc and stimulatory protein 1 in human ameloblastoma].

Abstract

OBJECTIVE:

To study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.

METHODS:

The expression was observed in AB by in situ hybridization and SP method.

RESULTS:

The positive rates of c-myc mRNA, hTERT mRNA and SP1 protein were 81.5% (44/54), 94.4% (51/54) and 83.3% (45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs = 0.853, P < 0.001; rs = 0.900, P < 0.001).

CONCLUSION:

Activity of telomerase plays an important role in the tumorigenesis development of AB. Increasing of hTERT expression may be related to c-myc and SP1. The expression of these three parameters has a significant correlation with the clinical biological characteristics of AB.

• Authors: Ming Zhong, Zi-juan Li, Jie Wang, Bo Zhang, Lin Hou, Yan-bing Gong
• Journal: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology (Hua Xi Kou Qiang Yi Xue Za Zhi) Vol. 22 Issue 6 Pg. 499-502 (Dec 2004) ISSN: 1000-1182 [Print] China
• PMID: 15656532 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MYC protein, human
• Proto-Oncogene Proteins c-myc
• Sp1 Transcription Factor
• Telomerase

Topics

• Ameloblastoma (metabolism)
• Humans
• Proto-Oncogene Proteins c-myc (metabolism)
• Sp1 Transcription Factor (metabolism)
• Telomerase (metabolism)