Abstract | BACKGROUND: METHODS:
Formalin-fixed, paraffin-embedded specimens from 132 colorectal cancers (Dukes' B, 36 cases; Dukes' C, 60 cases; and Dukes' D, 36 cases) treated by 5-FU post-operatively were immunostained for TS and p16(INK4a). Antigenicities were suitably retrieved. RESULTS: Primary tumors expressing high levels of TS in the Dukes' C group showed a significantly shorter recurrence-free interval (RFI) (P = 0.0002). The overall survival (OS) was shorter in high TS expressors than in low TS expressors (P = 0.001). A high level of TS expression also correlated with advanced Dukes' staging and the severity of nodal metastasis (Dukes' B versus Dukes' D, P = 0.001; Dukes' C versus Dukes' D, P = 0.008; N0 versus N2, P = 0.002; N1 versus N2, P = 0.03). p16(INK4a) expression was not correlated with the prognosis or clinicopathological features. CONCLUSIONS: Appropriate immunohistochemical evaluation is essentially important. We suggest that, in the Dukes' C group, a 5-FU-based regimen can be chosen as a first-line chemotherapy for low TS expressors. TS-high cancer should be treated with anti- cancer agents acting through different mechanisms. Further research should be conducted on applying TS immunostaining to the treatment strategy.
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Authors | Shingo Kamoshida, Hiroshi Matsuoka, Taro Ishikawa, Kotaro Maeda, Ryoichi Shimomura, Ken-ichi Inada, Yutaka Tsutsumi |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 34
Issue 10
Pg. 594-601
(Oct 2004)
ISSN: 0368-2811 [Print] England |
PMID | 15591457
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Cyclin-Dependent Kinase Inhibitor p16
- Drug Combinations
- UFT(R) drug
- Tegafur
- Uracil
- Thymidylate Synthase
- Fluorouracil
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Topics |
- Antimetabolites, Antineoplastic
(administration & dosage)
- Antineoplastic Agents
(administration & dosage)
- Chemotherapy, Adjuvant
- Colonic Neoplasms
(drug therapy, metabolism, pathology)
- Cyclin-Dependent Kinase Inhibitor p16
(biosynthesis)
- Drug Combinations
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Invasiveness
- Postoperative Period
- Rectal Neoplasms
(drug therapy, metabolism, pathology)
- Tegafur
(administration & dosage)
- Thymidylate Synthase
(metabolism)
- Uracil
(administration & dosage)
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