Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer.

Abstract	Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions.
Authors	Caroline L Holloway, Don Robinson, Brad Murray, John Amanie, Charles Butts, Michael Smylie, Karen Chu, A J McEwan, Ross Halperin, Wilson H Roa
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 73 Issue 3 Pg. 285-7 (Dec 2004) ISSN: 0167-8140 [Print] Ireland
PMID	15588872 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
Topics	Aged Carcinoma, Non-Small-Cell Lung (pathology, radiotherapy) Dose Fractionation, Radiation Dose-Response Relationship, Radiation Female Humans Lung Neoplasms (pathology, radiotherapy) Male Middle Aged Positron-Emission Tomography Radiation Pneumonitis Tomography, X-Ray Computed

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