Effect of gender on reporting of MMR adverse events in Saudi Arabia.

Abstract

We evaluated the safety of a measles-mumps-rubella (MMR) immunization campaign for Saudi children (age range: 6-13 years) and gender differences in reporting post-MMR adverse events. After vaccinations were administered, we monitored 160 schools for 14 days and 19 hospitals in the 8 cities under study for 10 weeks. Incidence rates were: all MMR adverse events, 26.5/10,000 MMR vaccines (significantly higher in females than males); Urabe strain aseptic meningitis, 1.0/295,000; fever, 40.2/10,000 (females) and 0.9/10,000 (males); and parotitis, 5.4/10,000 (females) and 0.9/10,000 (males). Combined MMR vaccine containing the Urabe mumps strain was safe for children aged 6-13 years. Gender differences regarding reactogenicity were evident and should be considered when designing future studies.

• Authors: M K Khalil, Y Y Al-Mazrou, Y S Al-Ghamdi, S Tumsah, M Al-Jeffri, A Meshkhas
• Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (East Mediterr Health J) 2003 Jan-Mar Vol. 9 Issue 1-2 Pg. 152-8 ISSN: 1020-3397 [Print] Egypt
• PMID: 15562745 (Publication Type: Journal Article)

Chemical References

• Measles-Mumps-Rubella Vaccine

Topics

• Adolescent
• Adverse Drug Reaction Reporting Systems (standards)
• Body Mass Index
• Child
• Data Collection (standards)
• Drug Hypersensitivity (epidemiology, etiology)
• Female
• Fever (epidemiology, etiology)
• Humans
• Immunization Programs (organization & administration)
• Incidence
• Male
• Measles-Mumps-Rubella Vaccine (adverse effects, metabolism, pharmacokinetics)
• Meningitis, Aseptic (epidemiology, etiology)
• Metabolic Clearance Rate
• Parotitis (epidemiology, etiology)
• Population Surveillance
• Program Evaluation
• Risk Factors
• Safety
• Saudi Arabia (epidemiology)
• Sex Characteristics
• Sex Distribution