Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation.

Abstract

During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.

• Authors: Paul Jurasz, David Alonso-Escolano, Marek W Radomski
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 143 Issue 7 Pg. 819-26 (Dec 2004) ISSN: 0007-1188 [Print] England
• PMID: 15492016 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Platelet Aggregation Inhibitors

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Blood Platelets (drug effects, pathology)
• Humans
• Neoplasms (blood, drug therapy, pathology)
• Platelet Aggregation (drug effects, physiology)
• Platelet Aggregation Inhibitors (pharmacology)