[Antiarrhythmic and cardioprotective effect of stimulation of delta1-opiate receptors in myocardial ischemia and reperfusion].

Abstract

Pretreatment with intravenous peptide delta1-opioid receptor (OR) agonist DPDPE (0.5 mg/kg) decreases the incidence of occlusion (10 min) and reperfusion (10 min) arrhythmias in rats. The agonist of delta2-OR DSLET has no effect on arrhythmias in coronary artery occlusion and reperfusion. Pretreatment with selective delta-antagonists ICI 174,864 (2.5 mg/kg) eliminates an antiarrhythmic effect of DPDPE. The addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/l and/or 0.5 mg/l fifteen min before ischemia also decreases the incidence of reperfusion arrhythmias in a concentration-dependent manner. The addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/l decreases creatine kinase levels in the coronary sinus effluent. However, DPDPE has no cardioprotective effect in a concentration of 0.5 mg/l or after intravenous administration. It is suggested that antiarrhythmic and cardioprotective effects of DPDPE during reperfusion may be due to stimulation of cardiac delta1-receptors.

• Authors: T V Lasukova, A V Krylatov, L N Maslov, Iu B Lishmanov, G J Gross, Iu K Podoksenov, A Iu Podoksenov
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2004 Jul-Sep Issue 3 Pg. 12-5 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Antiaritmicheskiĭ i kardioprotektornyĭ éffekt stimuliatsii delta1-opiatnykh retseptorov v usloviiakh ishemii i reperfuzii miokarda.
• PMID: 15446414 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Cardiotonic Agents
• Receptors, Opioid, delta
• Enkephalin, Leucine
• enkephalin, Ser(2), Leu(5), Thr(6)-
• Enkephalin, D-Penicillamine (2,5)-
• N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine
• Creatine Kinase

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Cardiotonic Agents (pharmacology)
• Creatine Kinase (drug effects)
• Dose-Response Relationship, Drug
• Enkephalin, D-Penicillamine (2,5)- (pharmacology)
• Enkephalin, Leucine (analogs & derivatives, pharmacology)
• Male
• Myocardial Ischemia (drug therapy, metabolism)
• Myocardial Reperfusion
• Myocardial Reperfusion Injury (drug therapy, prevention & control)
• Rats
• Receptors, Opioid, delta (agonists, antagonists & inhibitors, drug effects)