[Efficacy of 14 day OBMT therapy as a second-line treatment for Helicobacter pylori infection].

Abstract

BACKGROUND/AIMS:

As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80%, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy.

METHODS:

Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori.

RESULTS:

After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3%) and in 68 of 71 peptic ulcer patients (95.8%).

CONCLUSIONS:

Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90%.

• Authors: Sung Chul Park, Hoon Jai Chun, Sung Woo Jung, Bora Keum, Woo Sik Han, Rok Son Choung, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu, Jin Hai Hyun
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 44 Issue 3 Pg. 136-41 (Sep 2004) ISSN: 1598-9992 [Print] Korea (South)
• PMID: 15385721 (Publication Type: Journal Article)

Chemical References

• Antacids
• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Metronidazole
• Tetracycline
• Omeprazole
• Bismuth

Topics

• Adult
• Antacids (administration & dosage)
• Anti-Bacterial Agents (administration & dosage)
• Anti-Ulcer Agents (administration & dosage)
• Bismuth (administration & dosage)
• Drug Therapy, Combination
• Female
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Male
• Metronidazole (administration & dosage)
• Middle Aged
• Omeprazole (administration & dosage)
• Retreatment
• Tetracycline (administration & dosage)