Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis.

Abstract

OBJECTIVES:

Patients with end-stage renal disease (ESRD) who are receiving hemodialysis have an increased incidence of atherosclerotic heart disease. Currently, there is considerable controversy regarding the significance of elevated cardiac troponin I (cTnI) levels in patients with ESRD. The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis.

METHODS:

This was a prospective cohort study at an urban hospital outpatient dialysis center. Serum was collected pre- and postdialysis from patients on dialysis at this center over a two-week period. Samples were batched and analyzed for cTnI using the Asxym fluorescent antibody test. An elevated cTnI level was defined as >0.8 ng/dL.

RESULTS:

Predialysis cTnI levels ranged from <0.1 to 0.7 ng/dL, and postdialysis cTnI levels ranged from <0.1 to 0.6 ng/dL. None of the patients had a cTnI level >0.8 ng/dL.

CONCLUSIONS:

cTnI levels are not falsely elevated in patients with ESRD on hemodialysis. In a patient with ESRD, myocardial injury should be suspected if his or her cTnI level is >0.8 ng/dL.

• Authors: Michael W Donnino, Varnada Karriem-Norwood, Emanuel P Rivers, Ajay Gupta, H Bryant Nguyen, Gordon Jacobsen, James McCord, Michael C Tomlanovich
• Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (Acad Emerg Med) Vol. 11 Issue 9 Pg. 979-81 (Sep 2004) ISSN: 1069-6563 [Print] United States
• PMID: 15347551 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Troponin I

Topics

• Adult
• Aged
• Biomarkers
• Coronary Disease (blood, etiology)
• Humans
• Kidney Failure, Chronic (blood, complications, therapy)
• Middle Aged
• Prospective Studies
• Renal Dialysis
• Risk Factors
• Troponin I (blood)