HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.

Abstract
New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines
AuthorsAhmed Kamal, R Ramu, G B Ramesh Khanna, Ajit Kumar Saxena, M Shanmugavel, Renu Moti Pandita
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 19 Pg. 4907-9 (Oct 04 2004) ISSN: 0960-894X [Print] England
PMID15341949 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthraquinones
  • Antineoplastic Agents
  • Pyrroles
  • pyrrolo(2,1-c)(1,4)benzodiazepine
  • Benzodiazepines
  • DNA
Topics
  • Anthraquinones (chemical synthesis, metabolism, pharmacology)
  • Antineoplastic Agents (chemical synthesis, metabolism, pharmacology)
  • Benzodiazepines (chemical synthesis, metabolism, pharmacology)
  • Cell Line, Tumor
  • DNA (metabolism)
  • Drug Design
  • Humans
  • Pyrroles (chemical synthesis, metabolism, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: